Ontology highlight
ABSTRACT:
SUBMITTER: Mangan AJ
PROVIDER: S-EPMC4976216 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Mangan Anthony J AJ Sietsema Daniel V DV Li Dongying D Moore Jeffrey K JK Citi Sandra S Prekeris Rytis R
Nature communications 20160803
Coordinated polarization of epithelial cells is a key step during morphogenesis that leads to the formation of an apical lumen. Rab11 and its interacting protein FIP5 are necessary for the targeting of apical endosomes to the midbody and apical membrane initiation site (AMIS) during lumenogenesis. However, the machinery that mediates AMIS establishment and FIP5-endosome targeting remains unknown. Here we identify a FIP5-interacting protein, Cingulin, which localizes to the AMIS and functions as ...[more]