Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC4024058 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cellular logistics 20140101 1
Apical lumen formation is a key step during epithelial morphogenesis of tubular organs. Appropriate transport and targeting of apical proteins to the apical membrane initiation site (AMIS) plays a crucial role in establishing a solitary, central lumen. FIP5, a Rab11-interacting protein, is an important regulator that directs apical endosome trafficking along microtubules toward the AMIS during cytokinesis. However, it is unknown which molecular motor(s) transports FIP5-positive apical endosomes ...[more]