Ontology highlight
ABSTRACT:
SUBMITTER: De Rosa L
PROVIDER: S-EPMC4976335 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
De Rosa Lucia L Finetti Federica F Diana Donatella D Di Stasi Rossella R Auriemma Sara S Romanelli Alessandra A Fattorusso Roberto R Ziche Marina M Morbidelli Lucia L D'Andrea Luca Domenico LD
Scientific reports 20160808
The angiogenic properties of VEGF are mediated through the binding of VEGF to its receptor VEGFR2. The VEGF/VEGFR interface is constituted by a discontinuous binding region distributed on both VEGF monomers. We attempted to reproduce this discontinuous binding site by covalently linking into a single molecular entity two VEGF segments involved in receptor recognition. We designed and synthesized by chemical ligation a set of peptides differing in length and flexibility of the molecular linker jo ...[more]