Smartphone-enabled optofluidic exosome diagnostic for concussion recovery.
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ABSTRACT:
SUBMITTER: Ko J
PROVIDER: S-EPMC4976377 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Smartphone-enabled optofluidic exosome diagnostic for concussion recovery.
Ko Jina J Hemphill Matthew A MA Gabrieli David D Wu Leon L Yelleswarapu Venkata V Lawrence Gladys G Pennycooke Wesley W Singh Anup A Meaney Dave F DF Issadore David D
Scientific reports 20160808
A major impediment to improving the treatment of concussion is our current inability to identify patients that will experience persistent problems after the injury. Recently, brain-derived exosomes, which cross the blood-brain barrier and circulate following injury, have shown great potential as a noninvasive biomarker of brain recovery. However, clinical use of exosomes has been constrained by their small size (30-100 nm) and the extensive sample preparation (>24 hr) needed for traditional exos ...[more]
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