Targeting ubiquitination for cancer therapies.
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ABSTRACT:
SUBMITTER: Morrow JK
PROVIDER: S-EPMC4976843 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Targeting ubiquitination for cancer therapies.
Morrow John Kenneth JK Lin Hui-Kuan HK Sun Shao-Cong SC Zhang Shuxing S
Future medicinal chemistry 20151202 17
Ubiquitination, the structured degradation and turnover of cellular proteins, is regulated by the ubiquitin-proteasome system (UPS). Most proteins that are critical for cellular regulations and functions are targets of the process. Ubiquitination is comprised of a sequence of three enzymatic steps, and aberrations in the pathway can lead to tumor development and progression as observed in many cancer types. Recent evidence indicates that targeting the UPS is effective for certain cancer treatmen ...[more]
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