Ontology highlight
ABSTRACT:
SUBMITTER: Vogel S
PROVIDER: S-EPMC4976924 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Vogel Sebastian S Rath Dominik D Borst Oliver O Mack Andreas A Loughran Patricia P Lotze Michael T MT Neal Matthew D MD Billiar Timothy R TR Gawaz Meinrad M
Biochemical and biophysical research communications 20160720 1
Platelets are circulating cellular sensors that express and release the damage-associated molecular pattern molecule (DAMP) high-mobility group box 1 (HMGB1) at sites of disrupted vascular and tissue integrity. We have recently identified platelet-derived HMGB1 as a critical mediator of thrombosis. The role of platelet-derived HMGB1 in mediating interactions with monocytes remains unknown. In transgenic mice with platelet-specific ablation of HMGB1 and neutralization studies, we show that HMGB1 ...[more]