Ontology highlight
ABSTRACT:
SUBMITTER: Oyama Y
PROVIDER: S-EPMC3096665 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Oyama Yoko Y Hashiguchi Teruto T Taniguchi Noboru N Tancharoen Salunya S Uchimura Tomonori T Biswas Kamal K KK Kawahara Ko-Ichi K Nitanda Takao T Umekita Yoshihisa Y Lotz Martin M Maruyama Ikuro I
Laboratory investigation; a journal of technical methods and pathology 20100315 6
Granulomatous nephritis can be triggered by diverse factors and results in kidney failure. However, despite accumulating data about granulomatous inflammation, pathogenetic mechanisms in nephritis remain unclear. The DNA-binding high-mobility group box-1 protein (HMGB1) initiates and propagates inflammation when released by activated macrophages, and functions as an 'alarm cytokine' signaling tissue damage. In this study, we showed elevated HMGB1 expression in renal granulomas in rats with cryst ...[more]