Type 2 diabetes mellitus is associated with brain atrophy and hypometabolism in the ADNI cohort.

ABSTRACT:

Objective

We investigated type 2 diabetes mellitus (T2DM) as a risk factor for brain atrophy and glucose hypometabolism in older adults with or at risk of cognitive impairment.

Methods

Participants with the T2DM were identified from the Alzheimer's Disease Neuroimaging Initiative (ADNI-1/GO/2 cohorts). Analysis of covariance models were used to compare participants with and without T2DM, controlling for potential confounding factors.

Results

Whole brain volume and whole brain [(18)F]-fluorodeoxyglucose (FDG) uptake were significantly different as a function of T2DM status, independent of baseline clinical diagnosis. On post hoc analysis, a lower whole brain volume was seen in participants with both mild cognitive impairment (MCI) and T2DM (n = 76) compared with partic

SUBMITTER: Li W 

PROVIDER: S-EPMC4977372 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature