Dataset Information

Polycyclic Aromatic Hydrocarbons and Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Microliter Samples of Human Serum as Exposure Indicators.

ABSTRACT: OBJECTIVE:The objectives were: 1) measure polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) in 100??L of human serum and 2) assess PAH and PCDD/PCDF as markers of burn pit exposures during military deployments. METHODS:PAHs and PCDDs/PCDFs were analyzed in 100??L serum samples collected pre- and post-deployment from 200 persons deployed to Iraq or Afghanistan (CASE); 200 persons not deployed (CONTROL) with gas chromatography/mass spectrometry. RESULTS:Naphthalene was found in ?83% of the samples and was statistically different between post-deployment CASE personnel and pre-deployment. 1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin, Octachlorodibenzo-p-dioxin, 1,2,3,7,8,9-Hexachlorodibenzofuran, and 1,2,3,4,6,7,8-Heptachlorodibenzofuran were found in ?38% of samples. Concentrations were significantly different between CASE and CONTROL and between pre- and post-deployment samples. CONCLUSIONS:PAH and PCDD/PCDF in serum can serve as exposure markers and measurements in small volumes is feasible for quantifying exposure to burn pits.

SUBMITTER: Xia X

PROVIDER: S-EPMC4977992 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Publications

Polycyclic Aromatic Hydrocarbons and Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Microliter Samples of Human Serum as Exposure Indicators.

Xia Xiaoyan X Carroll-Haddad Alesia A Brown Nicole N Utell Mark J MJ Mallon Col Timothy M CT Hopke Philip K PK

Journal of occupational and environmental medicine 20160801 8 Suppl 1

<h4>Objective</h4>The objectives were: 1) measure polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) in 100 μL of human serum and 2) assess PAH and PCDD/PCDF as markers of burn pit exposures during military deployments.<h4>Methods</h4>PAHs and PCDDs/PCDFs were analyzed in 100 μL serum samples collected pre- and post-deployment from 200 persons deployed to Iraq or Afghanistan (CASE); 200 persons not deployed (CONTROL) with gas chromatograp ...[more]

PMID: 27501107

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Dataset Information

Polycyclic Aromatic Hydrocarbons and Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Microliter Samples of Human Serum as Exposure Indicators.

Publications

Polycyclic Aromatic Hydrocarbons and Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans in Microliter Samples of Human Serum as Exposure Indicators.

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