Ontology highlight
ABSTRACT:
SUBMITTER: Terker AS
PROVIDER: S-EPMC4978056 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Journal of the American Society of Nephrology : JASN 20151228 8
Excess aldosterone is an important contributor to hypertension and cardiovascular disease. Conversely, low circulating aldosterone causes salt wasting and hypotension. Aldosterone activates mineralocorticoid receptors (MRs) to increase epithelial sodium channel (ENaC) activity. However, aldosterone may also stimulate the thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC). Here, we generated mice in which MRs could be deleted along the nephron to test this hypothesis. These kidney-specific MR-kno ...[more]