Reconstruction of Networks with Direct and Indirect Genetic Effects.

ABSTRACT: Genetic variance of a phenotypic trait can originate from direct genetic effects, or from indirect effects, i.e., through genetic effects on other traits, affecting the trait of interest. This distinction is often of great importance, for example, when trying to improve crop yield and simultaneously control plant height. As suggested by Sewall Wright, assessing contributions of direct and indirect effects requires knowledge of (1) the presence or absence of direct genetic effects on each trait, and (2) the functional relationships between the traits. Because experimental validation of such relationships is often unfeasible, it is increasingly common to reconstruct them using causal inference methods. However, most current methods require all genetic variance to be explained by a sma

SUBMITTER: Kruijer W 

PROVIDER: S-EPMC7153926 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature