Ontology highlight
ABSTRACT:
SUBMITTER: Cui Y
PROVIDER: S-EPMC4978183 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Cui Yan Y Kam Kaiwen K Sherman David D Janczewski Wiktor A WA Zheng Yu Y Feldman Jack L JL
Neuron 20160801 3
Normal breathing in rodents requires activity of glutamatergic Dbx1-derived (Dbx1(+)) preBötzinger Complex (preBötC) neurons expressing somatostatin (SST). We combined in vivo optogenetic and pharmacological perturbations to elucidate the functional roles of these neurons in breathing. In transgenic adult mice expressing channelrhodopsin (ChR2) in Dbx1(+) neurons, photoresponsive preBötC neurons had preinspiratory or inspiratory firing patterns associated with excitatory effects on burst timing ...[more]