Ontology highlight
ABSTRACT:
SUBMITTER: Middleton S
PROVIDER: S-EPMC2587538 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Middleton Steven S Jalics Jozsi J Kispersky Tilman T Lebeau Fiona E N FE Roopun Anita K AK Kopell Nancy J NJ Whittington Miles A MA Cunningham Mark O MO
Proceedings of the National Academy of Sciences of the United States of America 20081107 47
Local circuits in the medial entorhinal cortex (mEC) and hippocampus generate gamma frequency population rhythms independently. Temporal interaction between these areas at gamma frequencies is implicated in memory-a phenomenon linked to activity of NMDA-subtype glutamate receptors. While blockade of NMDA receptors does not affect frequency of gamma rhythms in hippocampus, it exposes a second, lower frequency (25-35 Hz) gamma rhythm in mEC. In experiment and model, NMDA receptor-dependent mEC gam ...[more]