Ontology highlight
ABSTRACT:
SUBMITTER: Imamichi H
PROVIDER: S-EPMC4978246 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Imamichi Hiromi H Dewar Robin L RL Adelsberger Joseph W JW Rehm Catherine A CA O'Doherty Una U Paxinos Ellen E EE Fauci Anthony S AS Lane H Clifford HC
Proceedings of the National Academy of Sciences of the United States of America 20160718 31
Despite years of plasma HIV-RNA levels <40 copies per milliliter during combination antiretroviral therapy (cART), the majority of HIV-infected patients exhibit persistent seropositivity to HIV-1 and evidence of immune activation. These patients also show persistence of proviruses of HIV-1 in circulating peripheral blood mononuclear cells. Many of these proviruses have been characterized as defective and thus thought to contribute little to HIV-1 pathogenesis. By combining 5'LTR-to-3'LTR single- ...[more]