Ontology highlight
ABSTRACT:
SUBMITTER: Bruner KM
PROVIDER: S-EPMC5014606 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Bruner Katherine M KM Murray Alexandra J AJ Pollack Ross A RA Soliman Mary G MG Laskey Sarah B SB Capoferri Adam A AA Lai Jun J Strain Matthew C MC Lada Steven M SM Hoh Rebecca R Ho Ya-Chi YC Richman Douglas D DD Deeks Steven G SG Siliciano Janet D JD Siliciano Robert F RF
Nature medicine 20160808 9
Although antiretroviral therapy (ART) suppresses viral replication to clinically undetectable levels, human immunodeficiency virus type 1 (HIV-1) persists in CD4(+) T cells in a latent form that is not targeted by the immune system or by ART. This latent reservoir is a major barrier to curing individuals of HIV-1 infection. Many individuals initiate ART during chronic infection, and in this setting, most proviruses are defective. However, the dynamics of the accumulation and the persistence of d ...[more]