Ontology highlight
ABSTRACT:
SUBMITTER: Rohrs JA
PROVIDER: S-EPMC4978775 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Rohrs Jennifer A JA Wang Pin P Finley Stacey D SD
Cellular and molecular bioengineering 20160426
Lymphocyte-specific protein tyrosine kinase (LCK) is a key activator of T cells; however, little is known about the specific autoregulatory mechanisms that control its activity. We have constructed a model of LCK autophosphorylation and phosphorylation by the regulating kinase CSK. The model was fit to existing experimental data in the literature that presents an <i>in vitro</i> reconstituted membrane system, which provides more physiologically relevant kinetic measurements than traditional solu ...[more]