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Flow carbonylation of sterically hindered ortho-substituted iodoarenes.

ABSTRACT: The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse "tube-in-tube" flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.

SUBMITTER: Mallia CJ

PROVIDER: S-EPMC4979912 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Flow carbonylation of sterically hindered ortho-substituted iodoarenes.

Mallia Carl J CJ Walter Gary C GC Baxendale Ian R IR

Beilstein journal of organic chemistry 20160719

The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse "tube-in-tube" flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions. ...[more]

PMID: 27559403

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