Flow carbonylation of sterically hindered ortho-substituted iodoarenes.
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ABSTRACT: The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse "tube-in-tube" flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.
SUBMITTER: Mallia CJ
PROVIDER: S-EPMC4979912 | biostudies-literature |
REPOSITORIES: biostudies-literature
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