Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.
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ABSTRACT:
SUBMITTER: Shiraishi K
PROVIDER: S-EPMC4980483 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.
Shiraishi Kouya K Okada Yukinori Y Takahashi Atsushi A Kamatani Yoichiro Y Momozawa Yukihide Y Ashikawa Kyota K Kunitoh Hideo H Matsumoto Shingo S Takano Atsushi A Shimizu Kimihiro K Goto Akiteru A Tsuta Koji K Watanabe Shun-Ichi SI Ohe Yuichiro Y Watanabe Yukio Y Goto Yasushi Y Nokihara Hiroshi H Furuta Koh K Yoshida Akihiko A Goto Koichi K Hishida Tomoyuki T Tsuboi Masahiro M Tsuchihara Katsuya K Miyagi Yohei Y Nakayama Haruhiko H Yokose Tomoyuki T Tanaka Kazumi K Nagashima Toshiteru T Ohtaki Yoichi Y Maeda Daichi D Imai Kazuhiro K Minamiya Yoshihiro Y Sakamoto Hiromi H Saito Akira A Shimada Yoko Y Sunami Kuniko K Saito Motonobu M Inazawa Johji J Nakamura Yusuke Y Yoshida Teruhiko T Yokota Jun J Matsuda Fumihiko F Matsuo Keitaro K Daigo Yataro Y Kubo Michiaki M Kohno Takashi T
Nature communications 20160809
Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated ...[more]
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