Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5834153 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Zhang Y Y Zhang L L Li R R Chang D W DW Ye Y Y Minna J D JD Roth J A JA Han B B Wu X X
Annals of oncology : official journal of the European Society for Medical Oncology 20170701 7
<h4>Background</h4>Cancer initiation and development are driven by key mutations in driver genes. Applying high-throughput sequencing technologies and bioinformatic analyses, The Cancer Genome Atlas (TCGA) project has identified panels of somatic mutations that contributed to the etiology of various cancers. However, there are few studies investigating the germline genetic variations in these significantly mutated genes (SMGs) and lung cancer susceptibility.<h4>Patients and methods</h4>We compre ...[more]