Ontology highlight
ABSTRACT:
SUBMITTER: Kong Y
PROVIDER: S-EPMC4980550 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Kong Youxin Y Janssen Bert J C BJ Malinauskas Tomas T Vangoor Vamshidhar R VR Coles Charlotte H CH Kaufmann Rainer R Ni Tao T Gilbert Robert J C RJ Padilla-Parra Sergi S Pasterkamp R Jeroen RJ Jones E Yvonne EY
Neuron 20160707 3
Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nervous system development and plasticity, ranging from axon guidance and neuron migration to synaptic organization. PlxnA signaling requires cytoplasmic domain dimerization, but extracellular regulation and activation mechanisms remain unclear. Here we present crystal structures of PlxnA (PlxnA1, PlxnA2, and PlxnA4) full ectodomains. Domains 1-9 form a ring-like conformation from which the C-terminal domain 10 p ...[more]