Can a central blood volume deficit be detected by systolic pressure variation during spontaneous breathing?

ABSTRACT:

Background

Whether during spontaneous breathing arterial pressure variations (APV) can detect a volume deficit is not established. We hypothesized that amplification of intra-thoracic pressure oscillations by breathing through resistors would enhance APV to allow identification of a reduced cardiac output (CO). This study tested that hypothesis in healthy volunteers exposed to central hypovolemia by head-up tilt.

Methods

Thirteen healthy volunteers were exposed to central hypovolemia by 45° head-up tilt while breathing through a facemask with 7.5 cmH2O inspiratory and/or expiratory resistors. A brachial arterial catheter was used to measure blood pressure and thus systolic pressure variation (SPV), pulse pressure variation and stroke volume variation . Pulse contour analysis

SUBMITTER: Dahl M 

PROVIDER: S-EPMC4982018 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature