Ontology highlight
ABSTRACT:
SUBMITTER: Ma C
PROVIDER: S-EPMC4982030 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Ma Cong C Letort Aurélien A Aouzal Rémi R Wilkes Antonia A Maiti Gourhari G Farrugia Louis J LJ Ricard Louis L Prunet Joëlle J
Chemistry (Weinheim an der Bergstrasse, Germany) 20160408 20
Tricyclic isotaxane and taxane derivatives have been synthesized by a very efficient cascade ring-closing dienyne metathesis (RCDEYM) reaction, which formed the A and B rings in one operation. When the alkyne is present at C13 (with no neighboring gem-dimethyl group), the RCEDYM reaction leads to 14,15-isotaxanes 16 a,b and 18 b with the gem-dimethyl group on the A ring. If the alkyne is at the C11 position (and thus flanked by a gem-dimethyl group), RCEDYM reaction only proceeds in the presence ...[more]