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Major Persistent 5' Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues.

ABSTRACT: We performed deep sequencing analysis of the enterovirus 5' noncoding region in cardiac biopsies from a patient with dilated cardiomyopathy. Results displayed a mix of deleted and full-length coxsackievirus B3, characterized by a low viral RNA load (8.10(2) copies/μg of nucleic acids) and a low viral RNA positive-sense to RNA negative-sense ratio of 4.8.

SUBMITTER: Bouin A

PROVIDER: S-EPMC4982168 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Major Persistent 5' Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues.

Bouin Alexis A Nguyen Yohan Y Wehbe Michel M Renois Fanny F Fornes Paul P Bani-Sadr Firouze F Metz Damien D Andreoletti Laurent L

Emerging infectious diseases 20160801 8

We performed deep sequencing analysis of the enterovirus 5' noncoding region in cardiac biopsies from a patient with dilated cardiomyopathy. Results displayed a mix of deleted and full-length coxsackievirus B3, characterized by a low viral RNA load (8.10(2) copies/μg of nucleic acids) and a low viral RNA positive-sense to RNA negative-sense ratio of 4.8. ...[more]

PMID: 27434549

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