Ontology highlight
ABSTRACT:
SUBMITTER: Castel P
PROVIDER: S-EPMC4982440 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Castel Pau P Ellis Haley H Bago Ruzica R Toska Eneda E Razavi Pedram P Carmona F Javier FJ Kannan Srinivasaraghavan S Verma Chandra S CS Dickler Maura M Chandarlapaty Sarat S Brogi Edi E Alessi Dario R DR Baselga José J Scaltriti Maurizio M
Cancer cell 20160721 2
PIK3CA, which encodes the p110α subunit of PI3K, is frequently mutated and oncogenic in breast cancer. PI3Kα inhibitors are in clinical development and despite promising early clinical activity, intrinsic resistance is frequent among patients. We have previously reported that residual downstream mTORC1 activity upon treatment with PI3Kα inhibitors drives resistance to these agents. However, the mechanism underlying this phenotype is not fully understood. Here we show that in cancer cells resista ...[more]