GPR84 and TREM-1 Signaling Contribute to the Pathogenesis of Reflux Esophagitis.

ABSTRACT: Gastro-esophageal reflux disease (GERD) is one of the most common disorders in gastroenterology. Patients present with or without increased acid exposure indicating a nonuniform etiology. Thus, the common treatment with proton pump inhibitors (PPIs) fails to control symptoms in up to 40% of patients. To further elucidate the pathophysiology of the condition and explore new treatment targets, transcriptomics, proteomics and histological methods were applied to a surgically induced subchronic reflux esophagitis model in Wistar rats after treatment with either omeprazole (PPI) or STW5, a herbal preparation shown to ameliorate esophagitis without affecting refluxate pH. The normal human esophageal squamous cell line HET-1A and human endoscopic biopsies were used to confirm our findings to the

SUBMITTER: Abdel-Aziz H 

PROVIDER: S-EPMC4982478 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature