Ontology highlight
ABSTRACT:
SUBMITTER: Kos A
PROVIDER: S-EPMC4982812 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kos Aron A Olde Loohuis Nikkie N Meinhardt Julia J van Bokhoven Hans H Kaplan Barry B BB Martens Gerard J GJ Aschrafi Armaz A
Cellular and molecular life sciences : CMLS 20160326 18
MicroRNAs (miRs) are non-coding gene transcripts abundantly expressed in both the developing and adult mammalian brain. They act as important modulators of complex gene regulatory networks during neuronal development and plasticity. miR-181c is highly abundant in cerebellar cortex and its expression is increased in autism patients as well as in an animal model of autism. To systematically identify putative targets of miR-181c, we repressed this miR in growing cortical neurons and found over 70 d ...[more]