Tunable Lipidoid-Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4982832 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Tunable Lipidoid-Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment.
Wang Xu X Bodman Alexa A Shi Changying C Guo Dandan D Wang Lili L Luo Juntao J Hall Walter A WA
Small (Weinheim an der Bergstrasse, Germany) 20160704 31
A strategy to precisely engineer lipidoid-telodendrimer binary hybrid nanoparticles that offer enhanced cell membrane permeability for therapeutic proteins to reach the intracellular targets is established. The highly controllable biochemical and physical properties of the nanoparticles make them promising for protein-based brain cancer treatment with the assistance of convection-enhanced delivery. ...[more]
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