Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC5801074 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Wang Xu X Shi Changying C Wang Lili L Luo Juntao J
Colloids and surfaces. B, Biointerfaces 20171212
Intracellular delivery of protein therapeutics by cationic polymer vehicles is an emerging technique that is, however, encountering poor stability, high cytotoxicity and non-specific cell uptake. Herein, we present a facile strategy to optimize the protein-polycation complexes by encapsulating with linear-dendritic telodendrimers. The telodendrimers with well-defined structures enable the rational design and integration of multiple functionalities for efficient encapsulation of the protein-polyc ...[more]