Ontology highlight
ABSTRACT:
SUBMITTER: Frederick DW
PROVIDER: S-EPMC4985182 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Frederick David W DW Loro Emanuele E Liu Ling L Davila Antonio A Chellappa Karthikeyani K Silverman Ian M IM Quinn William J WJ Gosai Sager J SJ Tichy Elisia D ED Davis James G JG Mourkioti Foteini F Gregory Brian D BD Dellinger Ryan W RW Redpath Philip P Migaud Marie E ME Nakamaru-Ogiso Eiko E Rabinowitz Joshua D JD Khurana Tejvir S TS Baur Joseph A JA
Cell metabolism 20160801 2
NAD is an obligate co-factor for the catabolism of metabolic fuels in all cell types. However, the availability of NAD in several tissues can become limited during genotoxic stress and the course of natural aging. The point at which NAD restriction imposes functional limitations on tissue physiology remains unknown. We examined this question in murine skeletal muscle by specifically depleting Nampt, an essential enzyme in the NAD salvage pathway. Knockout mice exhibited a dramatic 85% decline in ...[more]