Ontology highlight
ABSTRACT:
SUBMITTER: Zhong YX
PROVIDER: S-EPMC4985661 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Zhong Yun-Xi YX Jin Xiao-Liang XL Gu Shi-Yin SY Peng Ying Y Zhang Ke-Rong KR Ou-Yang Bing-Chen BC Wang Yu Y Xiao Wei W Wang Zhen-Zhong ZZ Aa Ji-Ye JY Wang Guang-Ji GJ Sun Jian-Guo JG
Scientific reports 20160816
Guizhi Fuling capsule (GZFL), a traditional Chinese medicine formulation, is widely used in China to relieve pain from dysmenorrhea and is now in a Phase II clinical trial in the USA. Due to the low exposure of the five main medicative ingredients (amygdalin, cinnamic acid, gallic acid, paeoniflorin and paeonol) of GZFL in human, a strategy was built to qualitatively and quantitatively identify the possible metabolites of GZFL and to describe the pharmacokinetic profiles of GZFL in human. In thi ...[more]