Ontology highlight
ABSTRACT:
SUBMITTER: Han B
PROVIDER: S-EPMC4986332 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Human molecular genetics 20160221 9
Meta-analysis strategies have become critical to augment power of genome-wide association studies (GWAS). To reduce genotyping or sequencing cost, many studies today utilize shared controls, and these individuals can inadvertently overlap among multiple studies. If these overlapping individuals are not taken into account in meta-analysis, they can induce spurious associations. In this article, we propose a general framework for adjusting association statistics to account for overlapping subjects ...[more]