Ontology highlight
ABSTRACT:
SUBMITTER: Steinbach K
PROVIDER: S-EPMC4986533 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Steinbach Karin K Vincenti Ilena I Kreutzfeldt Mario M Page Nicolas N Muschaweckh Andreas A Wagner Ingrid I Drexler Ingo I Pinschewer Daniel D Korn Thomas T Merkler Doron D
The Journal of experimental medicine 20160704 8
Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown to enhance pathogen clearance by recruiting circulating immune cells and providing bystander activation. Here, we characterize the functioning of brain-resident memory T cells (bTRM) in an animal model of viral infection. bTRM were subject to spontaneous homeostatic proliferation and were largely refractory to systemic immune cell depletion. After viral reinfection in mice, bTRM rapidly acquired cytotoxi ...[more]