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Autonomous immunity in mucosal epithelial cells: fortifying the barrier against infection.

ABSTRACT: Mucosal epithelial cells express an autonomous innate immune response that controls the overgrowth of invaded bacteria, mitigates the harmful effects of the bacteria carried within, and does not rely on other external arms of the immune response. Epithelial cell autonomous innate immunity "respects" the social biology of invading bacteria to achieve symbiosis, and is the primary protective mechanism against pathogens.

SUBMITTER: Ross KF

PROVIDER: S-EPMC4884473 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Autonomous immunity in mucosal epithelial cells: fortifying the barrier against infection.

Ross Karen F KF Herzberg Mark C MC

Microbes and infection 20160319 6

Mucosal epithelial cells express an autonomous innate immune response that controls the overgrowth of invaded bacteria, mitigates the harmful effects of the bacteria carried within, and does not rely on other external arms of the immune response. Epithelial cell autonomous innate immunity "respects" the social biology of invading bacteria to achieve symbiosis, and is the primary protective mechanism against pathogens. ...[more]

PMID: 27005450

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