Ontology highlight
ABSTRACT:
SUBMITTER: Lehrbach NJ
PROVIDER: S-EPMC4987142 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Lehrbach Nicolas J NJ Ruvkun Gary G
eLife 20160816
Proteasomes are essential for protein homeostasis in eukaryotes. To preserve cellular function, transcription of proteasome subunit genes is induced in response to proteasome dysfunction caused by pathogen attacks or proteasome inhibitor drugs. In Caenorhabditis elegans, this response requires SKN-1, a transcription factor related to mammalian Nrf1/2. Here, we use comprehensive genetic analyses to identify the pathway required for C. elegans to detect proteasome dysfunction and activate SKN-1. G ...[more]