Skn-1a (Pou2f3) specifies taste receptor cell lineage.
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ABSTRACT:
SUBMITTER: Matsumoto I
PROVIDER: S-EPMC3390744 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Skn-1a (Pou2f3) specifies taste receptor cell lineage.
Matsumoto Ichiro I Ohmoto Makoto M Narukawa Masataka M Yoshihara Yoshihiro Y Abe Keiko K
Nature neuroscience 20110515 6
Functional diversification of taste cells is crucial for proper discrimination of taste qualities. We found the homeodomain protein Skn-1a (Pou2f3) to be expressed in sweet, umami and bitter taste cells. Skn-1a-deficient mice lacked electrophysiological and behavioral responses to sweet, umami and bitter tastes, as a result of a complete absence of sweet, umami and bitter cells and the concomitant expansion of sour cells. Skn-1a is critical for generating and balancing the diverse composition of ...[more]
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