Long term survival in persons with hemophilia and chronic hepatitis C: 40 year outcomes of a large single center cohort.
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ABSTRACT:
SUBMITTER: Eyster ME
PROVIDER: S-EPMC4987224 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Long term survival in persons with hemophilia and chronic hepatitis C: 40 year outcomes of a large single center cohort.
Eyster M Elaine ME Kong Lan L Li Menghan M Schreibman Ian R IR
American journal of hematology 20160714 9
We studied the course of chronic HCV infections in a cohort of 222 persons with hemophilia (PWH) and von Willebrand disease followed at our center since 1973. Twenty two (10%) developed end stage liver disease (ESLD). Forty years after HCV infection, cumulative incidence of ESLD was 12.3% and overall survival was 45.5%. Those who were infected with HCV only (n = 100) had a survival of 75.2%, while those infected with HIV (n = 122) had a survival of 24% (P < 0.001). Survivals were significantly l ...[more]
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