Ontology highlight
ABSTRACT:
SUBMITTER: McHugh E
PROVIDER: S-EPMC4987487 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
McHugh Emma E Batinovic Steven S Hanssen Eric E McMillan Paul J PJ Kenny Shannon S Griffin Michael D W MD Crawford Simon S Trenholme Katharine R KR Gardiner Donald L DL Dixon Matthew W A MW Tilley Leann L
Molecular microbiology 20150925 6
The malaria parasite Plasmodium falciparum dramatically remodels its host red blood cell to enhance its own survival, using a secretory membrane system that it establishes outside its own cell. Cisternal organelles, called Maurer's clefts, act as a staging point for the forward trafficking of virulence proteins to the red blood cell (RBC) membrane. The Ring-EXported Protein-1 (REX1) is a Maurer's cleft resident protein. We show that inducible knockdown of REX1 causes stacking of Maurer's cleft c ...[more]