Ontology highlight
ABSTRACT:
SUBMITTER: Lamprecht DA
PROVIDER: S-EPMC4987515 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Lamprecht Dirk A DA Finin Peter M PM Rahman Md Aejazur MA Cumming Bridgette M BM Russell Shannon L SL Jonnala Surendranadha R SR Adamson John H JH Steyn Adrie J C AJ
Nature communications 20160810
The Mycobacterium tuberculosis (Mtb) electron transport chain (ETC) has received significant attention as a drug target, however its vulnerability may be affected by its flexibility in response to disruption. Here we determine the effect of the ETC inhibitors bedaquiline, Q203 and clofazimine on the Mtb ETC, and the value of the ETC as a drug target, by measuring Mtb's respiration using extracellular flux technology. We find that Mtb's ETC rapidly reroutes around inhibition by these drugs and in ...[more]