Ontology highlight
ABSTRACT:
SUBMITTER: Maueroder C
PROVIDER: S-EPMC4987737 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Maueröder C C Chaurio R A RA Dumych T T Podolska M M Lootsik M D MD Culemann S S Friedrich R P RP Bilyy R R Alexiou C C Schett G G Berens C C Herrmann M M Munoz L E LE
Cell death and differentiation 20160304 6
In this study, we deploy a doxycycline-dependent suicide switch integrated in a tumor challenge model. With this experimental setup, we characterized the immunological consequences of cells dying by four distinct cell death stimuli in vivo. We observed that apoptotic cell death induced by expression of the truncated form of BH3 interacting-domain death agonist (tBid) and a constitutively active form of caspase 3 (revC3), respectively, showed higher immunogenicity than cell death induced by expre ...[more]