MCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures.
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ABSTRACT:
SUBMITTER: Pires DE
PROVIDER: S-EPMC4987957 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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mCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures.
Pires Douglas E V DE Ascher David B DB
Nucleic acids research 20160523 W1
Computational methods have traditionally struggled to predict the effect of mutations in antibody-antigen complexes on binding affinity. This has limited their usefulness during antibody engineering and development, and their ability to predict biologically relevant escape mutations. Here we present mCSM-AB, a user-friendly web server for accurately predicting antibody-antigen affinity changes upon mutation which relies on graph-based signatures. We show that mCSM-AB performs better than compara ...[more]
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