Dataset Information
Time on timing: Dissociating premature responding from interval sensitivity in Parkinson's disease.
Ontology highlight
ABSTRACT: Background
Parkinson's disease (PD) can cause impulsivity with premature responses, but there are several potential mechanisms. We proposed a distinction between poor decision-making and the distortion of temporal perception. Both effects may be present and interact, but with different clinical and pharmacological correlates.Objectives
This study assessed premature responding during time perception in PD.Methods
In this study, 18 PD patients and 19 age-matched controls completed 2 temporal discrimination tasks (bisection and trisection) and a baseline reaction-time task. Timing sensitivity and decision-making processes were quantified by response and response time. An extended version of the modified difference model was used to examine the precision of time representation and the modulation of response time by stimulus ambiguity.Results
In the bisection task, patients had a lower bisection point (P?ConclusionsThese findings suggest that timing deficits in PD cannot be solely attributed to perceptual distortions, but are also associated with impulsive decision strategies that bias patients toward premature responses. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
SUBMITTER: Zhang J
PROVIDER: S-EPMC4988382 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Time on timing: Dissociating premature responding from interval sensitivity in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 20160419 8
<h4>Background</h4>Parkinson's disease (PD) can cause impulsivity with premature responses, but there are several potential mechanisms. We proposed a distinction between poor decision-making and the distortion of temporal perception. Both effects may be present and interact, but with different clinical and pharmacological correlates.<h4>Objectives</h4>This study assessed premature responding during time perception in PD.<h4>Methods</h4>In this study, 18 PD patients and 19 age-matched controls co ...[more]