Ontology highlight
ABSTRACT:
SUBMITTER: Mutz CN
PROVIDER: S-EPMC4988508 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
FEBS letters 20160621 14
Ewing sarcoma (ES) is an aggressive pediatric tumor driven by the fusion protein EWS-FLI1. We report that EWS-FLI1 suppresses TDO2-mediated tryptophan (TRP) breakdown in ES cells. Gene expression and metabolite analyses reveal an EWS-FLI1-dependent regulation of TRP metabolism. TRP consumption increased in the absence of EWS-FLI1, resulting in kynurenine and kynurenic acid accumulation, both aryl hydrocarbon receptor (AHR) ligands. Activated AHR binds to the promoter region of target genes. We d ...[more]