Ontology highlight
ABSTRACT:
SUBMITTER: Ramsook SN
PROVIDER: S-EPMC4988710 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Ramsook Sarah N SN Ni Joyce J Shahangian Shokofeh S Vakiloroayaei Ana A Khan Naveen N Kwan Jamie J JJ Donaldson Logan W LW
PloS one 20160817 8
Group E members of the SOX transcription factor family include SOX8, SOX9, and SOX10. Preceding the high mobility group (HMG) domain in each of these proteins is a thirty-eight amino acid region that supports the formation of dimers on promoters containing tandemly inverted sites. The purpose of this study was to obtain new structural insights into how the dimerization region functions with the HMG domain. From a mutagenic scan of the dimerization region, the most essential amino acids of the di ...[more]