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Genetic Variation in Schizophrenia Liability is Shared With Intellectual Ability and Brain Structure.


ABSTRACT:

Background

Alterations in intellectual ability and brain structure are important genetic markers for schizophrenia liability. How variations in these phenotypes interact with variance in schizophrenia liability due to genetic or environmental factors is an area of active investigation. Studying these genetic markers using a multivariate twin modeling approach can provide novel leads for (genetic) pathways of schizophrenia development.

Methods

In a sample of 70 twins discordant for schizophrenia and 130 healthy control twins, structural equation modeling was applied to quantify unique contributions of genetic and environmental factors on human brain structure (cortical thickness, cortical surface and global white matter fractional anisotropy [FA]), intellectual ability and schizophrenia liability.

Results

In total, up to 28.1% of the genetic variance (22.8% of total variance) in schizophrenia liability was shared with intelligence quotient (IQ), global-FA, cortical thickness, and cortical surface. The strongest contributor was IQ, sharing on average 16.4% of the genetic variance in schizophrenia liability, followed by cortical thickness (6.3%), global-FA (4.7%) and cortical surface (0.5%). Furthermore, we found that up to 57.4% of the variation due to environmental factors (4.6% of total variance) in schizophrenia was shared with IQ (34.2%) and cortical surface (13.4%).

Conclusions

Intellectual ability, FA and cortical thickness show significant and independent shared genetic variance with schizophrenia liability. This suggests that measuring brain-imaging phenotypes helps explain genetic variance in schizophrenia liability that is not captured by variation in IQ.

SUBMITTER: Bohlken MM 

PROVIDER: S-EPMC4988741 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Genetic Variation in Schizophrenia Liability is Shared With Intellectual Ability and Brain Structure.

Bohlken Marc M MM   Brouwer Rachel M RM   Mandl René C W RC   Kahn René S RS   Hulshoff Pol Hilleke E HE  

Schizophrenia bulletin 20160407 5


<h4>Background</h4>Alterations in intellectual ability and brain structure are important genetic markers for schizophrenia liability. How variations in these phenotypes interact with variance in schizophrenia liability due to genetic or environmental factors is an area of active investigation. Studying these genetic markers using a multivariate twin modeling approach can provide novel leads for (genetic) pathways of schizophrenia development.<h4>Methods</h4>In a sample of 70 twins discordant for  ...[more]

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