Ontology highlight
ABSTRACT:
SUBMITTER: Lee PH
PROVIDER: S-EPMC5144575 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Lee P H PH Baker J T JT Holmes A J AJ Jahanshad N N Ge T T Jung J-Y JY Cruz Y Y Manoach D S DS Hibar D P DP Faskowitz J J McMahon K L KL de Zubicaray G I GI Martin N G NG Wright M J MJ Öngür D D Buckner R R Roffman J J Thompson P M PM Smoller J W JW
Molecular psychiatry 20161011 12
Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic etiology. Widespread cortical gray matter loss has been observed in patients and prodromal samples. However, it remains unresolved whether schizophrenia-associated cortical structure variations arise due to disease etiology or secondary to the illness. Here we address this question using a partitioning-based heritability analysis of genome-wide single-nucleotide polymorphism (SNP) and neuroimaging data from 1750 he ...[more]