Metagene Profiles Analyses Reveal Regulatory Element's Factor-Specific Recruitment Patterns.

ABSTRACT: ChIP-Sequencing (ChIP-Seq) provides a vast amount of information regarding the localization of proteins across the genome. The aggregation of ChIP-Seq enrichment signal in a metagene plot is an approach commonly used to summarize data complexity and to obtain a high level visual representation of the general occupancy pattern of a protein. Here we present the R package metagene, the graphical interface Imetagene and the companion package similaRpeak. Together, they provide a framework to integrate, summarize and compare the ChIP-Seq enrichment signal from complex experimental designs. Those packages identify and quantify similarities or dissimilarities in patterns between large numbers of ChIP-Seq profiles. We used metagene to investigate the differential occupancy of regulatory factors at

SUBMITTER: Joly Beauparlant C 

PROVIDER: S-EPMC4990179 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature