Ontology highlight
ABSTRACT:
SUBMITTER: Zhang R
PROVIDER: S-EPMC4991380 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Zhang Rong R Zeng Hanyu H Zhang Yun Y Chen Kun K Zhang Chunmei C Song Chaojun C Fang Liang L Xu Zhuwei Z Yang Kun K Jin Boquan B Wang Qintao Q Chen Lihua L
Oncotarget 20160401 15
Treatment targeting CD226 can ameliorate experimental autoimmune encephalomyelitis (EAE), the widely accepted model of MS. However, the mechanisms still need to be elucidated. Here we showed that CD226 blockage by anti-CD226 blocking mAb LeoA1 efficiently promoted IL-10 production in human peripheral blood monocytes (PBMC) or in mixed lymphocyte culture (MLC) system, significantly induced the CD4+IL-10+ T cell differentiation while suppressing the generation of Th1 and Th17. Furthermore, CD226 p ...[more]