Ontology highlight
ABSTRACT:
SUBMITTER: Wang N
PROVIDER: S-EPMC7478170 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wang Ning N Yi Hongyu H Fang Liang L Jin Jingyi J Ma Qianli Q Shen Yuting Y Li Juan J Liang Shuang S Xiong Jie J Li Zhuo Z Zeng Hanyu H Jiang Fengliang F Jin Boquan B Chen Lihua L
Frontiers in immunology 20200821
Cluster of differentiation 226 (CD226) molecules play a crucial role in the activation of effector CD4<sup>+</sup> T cells during the immune response process, but a cell-intrinsic function of CD226 in CD4<sup>+</sup> T subsets is not clear. In this study, we showed that <i>Cd226</i><sup>-/-</sup> mice were resistant to myelin oligodendrocyte glycoprotein peptide 35-55 (MOG<sub>35-55</sub>)-induced experimental autoimmune encephalomyelitis (EAE) with highly expressed IL-10<sup>+</sup>CD4<sup>+</s ...[more]