Ontology highlight
ABSTRACT:
SUBMITTER: Ball DP
PROVIDER: S-EPMC4991483 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Oncotarget 20160401 15
The Signal Transducer and Activator of Transcription 3 (STAT3) oncogene is a master regulator of many human cancers, and a well-recognized target for therapeutic intervention. A well known STAT3 inhibitor, S3I-201 (NSC 74859), is hypothesized to block STAT3 function in cancer cells by binding the STAT3 SH2 domain and disrupt STAT3 protein complexation events. In this study, liquid chromatography tandem mass spectrometry analysis revealed that STAT3, in the presence of S3I-201, showed a minimum o ...[more]