Ontology highlight
ABSTRACT:
SUBMITTER: Wang SSH
PROVIDER: S-EPMC4991631 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Wang Shan Shan H SSH Held Richard G RG Wong Man Yan MY Liu Changliang C Karakhanyan Aziz A Kaeser Pascal S PS
Neuron 20160801 4
In a nerve terminal, synaptic vesicle docking and release are restricted to an active zone. The active zone is a protein scaffold that is attached to the presynaptic plasma membrane and opposed to postsynaptic receptors. Here, we generated conditional knockout mice removing the active zone proteins RIM and ELKS, which additionally led to loss of Munc13, Bassoon, Piccolo, and RIM-BP, indicating disassembly of the active zone. We observed a near-complete lack of synaptic vesicle docking and a stro ...[more]